Nina Dobrev ~ Elena Gilbert & Katherine Pierce/Petrova
Ian Somerhalder ~ Damon Salvatore
Paul Wesley ~ Stefan Salvatore
Candice Accola ~ Caroline Forbes
Michael Trevino ~ Tyler Lockwood
Zach Roerig ~ Matt Donovan
Katherina Graham ~ Bonnie Bennett
Matt Davis ~ Alaric Saltzman
Sara Canning ~ Jenna Sommers
Steven R. McQueen ~ Jeremy Gilbert
David Anders ~ John Gilbert
Marguerite MacIntyre ~ Sheriff Forbes

Guest appearances and recurring characters
Kayla Ewell ~ Vicky Donovan
Susan Walters ~ Carol Lockwood
Robert Pralgo ~ Mayor Lockwood
Chris William Martin Zach Salvatore
Bianca Lawson ~ Emily Bennett
Jasmine Guy ~ Grams
Chris J. Johnson ~ Logan Fell
Malese Jow ~ Anna(belle)
Sean Faris ~ Ben McKittrick
Kelly Hu ~ Pearl
Melinda Clarke ~ Kelly Donovan
Taylor Kinney ~ Mason Lockwood
Daniel Gillies ~ Elijah
Bryton James ~ Luka Martin
Randy J. Goodwin ~ Dr. Martin
Lauren Cohan ~ Rose
Trent Ford ~ Trevor
Mia Kirshner ~ Isobel Flemming
Michaela McManus ~ Jules
Dawn Olivieri ~ Andi Star
Greta Martin ~ Lisa Tucker
Maddox ~ Gino Anthony Pesi